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desvenlafaxine will raise the stage or outcome of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Desvenlafaxine inhibits CYP2D6; with bigger desvenlafaxine doses (ie, 400 mg) lower the CYP2D6 substrate dose by around fifty%; no dosage adjustment desired with desvenlafaxine doses seven consecutive days promptly just befo